The heterogeneity of cancer cells introduces significant challenges in designing effective. Role of tumor heterogeneity in drug resistance peertechz. Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Colorectal cancer crc is a highly heterogeneous disease, with pathologically similar cancers having completely different responses to treatment and patient survival. Populations of tumour cells display remarkable variability in almost every discernable phenotypic trait, including clinically important phenotypes such as ability to seed metastases and to survive therapy. Tumour heterogeneity and cancer cell plasticity nature. Intratumour heterogeneity ith has been documented for many decades, initially from a morphological perspective 1, 2. Indeed, structural and functional tumor heterogeneities are strongly associated with primary and secondary resistance to antitumor treatments 2. Understanding the mechanisms of tumor heterogeneity and drug resistance. Similarly to other cancers, improvement of outcomes for patients with gbm is highly dependent on a better understanding of the biology of gbm, including tumor heterogeneity in all its dimensions. Andriy marusyk 1, vanessa almendro 1,2 and kornelia polyak 1 abstract populations of tumour cells display remarkable variability in almost. Structural and functional intratumor heterogeneities in. Populations of tumour cells display remarkable variability in almost every discernable phenotypic trait, including clinically important phenotypes such as ability to. Tumour heterogeneity describes the observation that different tumour cells can show distinct.
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